Ghrelin induces growth hormone (GH) secretion via nitric oxide (NO)/cGMP signaling.
نویسندگان
چکیده
Ghrelin, a recently discovered 28-aa peptide, stimulates GH release through a mechanism involving PLC- and cAMP-related signaling pathways. Recently, nitric oxide (NO) and its mediator, cGMP, have been shown to be required for the response of somatotropes to various regulators (GHRH, somatostatin, leptin). Here, we explore the possible role of the NO synthase (NOS)/NO/guanylate cyclase (GC)/cGMP signaling pathway in ghrelin-induced GH release from cultured pig somatotropes using blockers or activators of this route.
منابع مشابه
Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids.
Ghrelin is a 28-amino-acid peptide, with an essential n-octanoyl modification at Ser3, that elicits growth-hormone (GH) secretion in rats and humans. At present, the mechanisms of ghrelin action and its interactions with other systems controlling GH secretion remain poorly characterized. In this context, the present study was undertaken to obtain information about ontogeny and possible gender d...
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 1040 شماره
صفحات -
تاریخ انتشار 2005